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Treatment Strategies targeting TAMs. (1) Inhibition of TAM recruitment by blocking the CCL2/CCR2 or CXCL2/CXCR4 axis. (2) Depletion of TAMs by blocking the CSF-1/CSF-1R axis or using compounds such as bisphosphonates or trabectedin. (3) Reprogramming of TAMs to activate their anti-cancer function by CD47/STRPα pathway inhibitors, MHC I/LILRB1 pathway inhibitors, CD40 agonists, toll-like receptors agonists, Glufosinate, PI3Kγ inhibitors, or HDAC inhibitors.
