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. 2021 Jun 10;11:643129. doi: 10.3389/fonc.2021.643129

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Copyright © 2021 Bi, An, Sun, You and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PHGDH is increased in platin-resistant ovarian cancer and predicts poor prognosis of patients with ovarian cancer. (A) PHGDH expression was assessed using Western blot in platin-sensitive (parental) and their platin-resistant (DDP) SKOV3 and A2780 cells. The relative expression was noted under the blots. (B) PHGDH expression was investigated in 16 cisplatin-sensitive and nine cisplatin-resistant ovarian cancer tissues using Western blot. (C) Ovarian cancer tissue microarray was subjected to immunohistochemical staining, and representative images of immunohistochemistry staining with PHGDH were presented. (D) Kalpan–Meier plot shows the overall survival of patients with ovarian cancer grouped by PHGDH expression.