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. 2021 Jun 10;9:689947. doi: 10.3389/fcell.2021.689947

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Copyright © 2021 Xuan, Chen, Tang, Ye, Zheng, Zhao, Shi, Zhang, Sun and Shao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Renal cancer exosomes promote ccRCC metastasis. (A) The mice were injected with 786-O cells via tail vein after exposure to 786-O or 786-O-SR exosomes. The lungs were removed for H&E staining after 15 days. (B) IHC staining for CD34-positive cells. Mean ± SEM are provided (n = 3). (C) The lungs were removed after 30 days. Lung metastatic sites were indicated by arrows. (D) The number of lung metastatic sites was counted under the microscope. Mean ± SEM are provided (n = 4). Scale bar 200 μm. (E) Effect of exosomes of 786-O/786-O-SR on introtumoral microvessel density. The number of microvessel was counted under the microscope. Mean ± SEM are provided (n = 3). ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 according to two-tailed Student’s t-test.