Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Lactate metabolism is implicated in the tumor microenvironment. (A) The main biochemical players in lactate generation: the glycolytic pathway and OXPHOS. (B) Role of lactate in the TME, including tumor, stromal, immune cells, blood vessels and cellular metabolites such as lactate. As a consequence of the Warburg effect and the lactate shuttle, lactate accumulation induces acidosis, angiogenesis, immunosuppression, and tumor cell proliferation and survival.
