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. 2021 Jun 10;12:632295. doi: 10.3389/fphar.2021.632295

FIGURE 4.

FIGURE 4

Presentation of the retina after retrobulbar L-NAME application (without therapy (regular font) and with BPC 157 therapy (italic font)) from day 2 (D, D, a, and b) until the end of the experiment (day 3, c; week 1 (E, E, and e); week 2 (F, F, and f); week 4 (G, G, and g)). Rats received. therapy at 20 min (all capitals, D, E, F, and G (saline) or D, E, F, and G (BPC 157)) or at 48 h after L-NAME (small letters, a, b, c, d, e, and f (BPC 157)). Presentation of the retina at 2 days after retrobulbar administered L-NAME (D, D, a, and b). D. Saline application (at 20 min, or at 48 h after L-NAME). The retina presentation of the rats like in the rats that received L-NAME only (data not specifically shown). Strong generalized irregularity diameter blood vessels with severe atrophy of the optic disc, extremely poor presentation of the choroidal blood vessels. D. BPC 157 therapy at 20 min after retrobulbar L-NAME. Normal eye background, normal presentation of the choroidal blood vessels. a,b,c. BPC 157 therapy at 48 hours after retrobulbar L-NAME. a. Presentation of the retina immediately after retrobulbar BPC 157 application. Discrete generalized irregularity diameter blood vessels with mild atrophy of the optic disc, normal presentation of the choroidal blood vessels. b. Presentation of the retina at 20 min after retrobulbar BPC 157 application. Normal eye background, normal presentation of the choroidal blood vessels. c. Presentation of the retina at 1 day after retrobulbar BPC 157 application. Normal eye background, normal presentation of the choroidal blood vessels. Presentation of the retina at 1 week after retrobulbar administered L-NAME (E, E, e). E. Strong generalized irregularity diameter blood vessels with severe atrophy of the optic disc, extremely poor presentation of the choroidal blood vessels (saline). BPC 157 therapy at 20 minutes (E) or at 48 h after retrobulbar L-NAME (e). E, e. Normal eye background, normal presentation of the choroidal blood vessels. Presentation of the retina at 2 weeks after retrobulbar administered L-NAME (F, F, f). F. Strong generalized irregularity diameter blood vessels with severe atrophy of the optic disc, extremely poor presentation of the choroidal blood vessels (saline). BPC 157 therapy at 20 minutes (F) or at 48 h after retrobulbar L-NAME (f).F, f. Normal eye background, normal presentation of the choroidal blood vessels. Presentation of retina at 4 weeks after retrobulbar administered L-NAME (G, G, g). G. Strong generalized irregularity diameter blood vessels with severe atrophy of the optic disc, extremely poor presentation of the choroidal blood vessels (saline). BPC 157 therapy at 20 min (G) or at 48 h after retrobulbar L-NAME (g).G, g. Normal eye background, normal presentation of the choroidal blood vessels. The images are processed with software purchased with a USB microscope camera “Veho Discovery VMS-004 Deluxe”.