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. 2021 Jun 10;12:632295. doi: 10.3389/fphar.2021.632295

FIGURE 9.

FIGURE 9

Retrobulbar L-NAME application induced retinal damage. Rats behavior presentation after retrobulbar agent’s application. Left. Saline retrobulbar application(s) completely preserved rats behavior and they did not present freezing behavior while investigated (S + S). Right. L-NAME retrobulbar application (total dose 5 mg/kg, which was divided by the retrobulbar application in each eye, 0.5 mg/0.1 ml saline/eye) (L-NAME retrobulbar application +). Rats underwent L-NAME that received BPC 157 therapy (total dose 10 μg/kg or 10 ng/kg as retrobulbar application in each eye, 1 μg/0.1 ml saline/eye or 1 ng/0.1 ml saline/eye) at 20 min [B μg (+20 min), B ng (+20 min)], or 48 h [B μg (+48 h)]. Rats presented behavior without any freezing behavior. Rats underwent L-NAME that received saline as therapy [saline only as retrobulbar application in each eye (0.1 ml/eye)] [since no different the rats underwent L-NAME that received saline retrobulbar application were presented together (+S (control)]. Rats continuously presented mostly freezing behavior while investigated. *p<0.05, at least vs. control. 10 rats per experimental group and period for all experiments.