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. 2021 Jun 10;12:691216. doi: 10.3389/fimmu.2021.691216

Figure 6.

Figure 6

Correlations between bacterial species and lipid mediators in the three groups. (A) correlated lipid mediators and bacterial species in the healthy group. (B) correlated lipid mediators and bacterial species in the periodontitis before non-surgical therapy group. (C) correlated lipid mediators and bacterial species in the periodontitis after non-surgical therapy group. The analysis is performed using the Sparse Partial Least Squares (SPLS) method. Bacterial species are listed in alphabetical order. Lipid mediators are grouped by biosynthetic pathways; leukotriene pathway marker: 5(S),6(R)-DiHETE; lipoxygenase pathway marker: 5(S),12(S)-DiHETE; prostaglandin pathway marker: 12(S)-HHTrE; E-series resolvins and pathway markers (derived from omega-3 EPA): 15(S)-HEPE, 18-HEPE, RvE3; D-series resolvins and pathway markers (derived from omega-3 DHA or DPA): RvD1, 7-HDHA, 13-HDHA; Maresins and pathway markers (derived from omega-3 DHA or DPA): 14-HDHA, MaR1, 7(S)-MaR1; pro-inflammatory lipid mediators: LTB4, PGD2, PGE2, PGF2a. Some pathway markers are involved in multiple pathways but only one major pathway is listed. All correlated lipid mediators-bacterial species have absolute correlation coefficients ≥0.60.