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. 2021 Jun 10;11:610742. doi: 10.3389/fonc.2021.610742

Table 3.

Univariate analysis of preoperative clinical factors associated with metastasis.

Characteristics Training cohort P Validation cohort P
Metastasis (–) (n = 20) Metastasis (+) (n = 50) Metastasis (-) (n = 10) Metastasis (+) (n = 21)
Age (years), 0.012* 0.018*
Mean (range) 48.4 (23-76) 57.9 (29-79) 43.8 (15-61) 56.1 (26-70)
Weight (kg) 0.92 0.06
Mean (range) 57.0 (47-75) 56.9 (42-76) 60.1 (51-66) 57.2 (43-81)
TCHO (mmol/L) 0.59 0.25
≤5.2 11 31 4 13
>5.2 9 19 6 8
TG (mmol/L) 0.73 0.70
≤1.7 14 37 7 16
>1.7 6 13 3 5
HDLC (mmol/L) 0.11 0.74
≤2 19 50 9 18
>2 1 0 1 3
LDLC (mmol/L) 0.70 0.05
≤3.12 13 30 4 16
>3.12 7 20 6 5
Blood sugar (mmol/L) 0.88 0.21
≤6.1 10 26 8 12
>6.1 10 24 2 9
CA125 (U/ml) < 0.001* 0.001*
≤35 7 2 6 1
>35 13 48 4 20
CEA (ng/ml) 0.38 0.95
≤5 15 32 8 17
>5 5 18 2 4

*P value < 0.05; Categorical variables were compared by using the chi-square test. Continues variables were compared by using the Student t test or Mann-Whitney U test;

TCHO, total cholesterol; TG, triglyceride; HDLC, high density lipoprotein; LDLC, low density lipoprotein; CA125, carcinoma antigen 125; CEA, carcinoembryonic antigen.