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. 2021 May 13;8(3):414–434. doi: 10.3934/Neuroscience.2021022

Table 1. Baseline characteristics of the included studies.

First Author, Publication Year Study Type Study Period (Days) Mean Age (SD) in Years Participants at baseline (n) Participants Analyzed at FUP (n) Gender (% Females) Cannabis Intervention Comparator Permitted Co-Interventions
Cameron, 2014 Retrospective chart review 1 to 252 32.7 (range: 19 to 55) 104 84 0 Nabilone; powdered form; final dosage range: 0.5–6.0 mg N/A Antipsychotics, sedative/hypnotics, antidepressants, antiadrenergic, NSAIDs, Acetaminophen, Opioids, Anticonvulsants, cyclobenzaprine, prednisone
Chan, 2017 Prospective (survey) 639 43.25 (range: 19 to 70) 588 540 22.28 Various varieties of cannabis; same provider N/A N/A
Drost, 2017 Prospective (survey) 120 N/A 647 Not clear N/A Various varieties of cannabis; Indica-dominant or leaning, Sativa dominant or leaning NA N/A
Elms, 2019 Retrospective (case series) 56 39.91 (17.39) 21 11 73 Cannabidiol (CBD); oral capsule or liquid spray; mean total dosage: 33.18 mg-48.64 mg N/A Anticonvulsant, antidepressant, antipsychotic, anxiolytic/sedative, beta-blocker; dietary changes, herbal supplementation, neurofeedback, and intravenous infusions of vitamins and minerals
Greer, 2014 Retrospective (chart review) N/A N/A 80 80 N/A Various varieties of cannabis No-cannabis control N/A
Jetly, 2015 RCT (cross-over) 49 43.6 (8.2) 10 9 0 Nabilone; Cesamet & Valeant Canada tablets; dosage range: 0.5–3.0 mg Matching placebo; Waitlist control Antidepressants
Johnson, 2016 cross-sectional N/A 47.1 700 700 9 Various varieties of cannabis Case-matched non-users' control N/A
Roitman, 2014 Prospective (open-label, preliminary) 21 52.3 (8.3) 10 10 30 THC; Dosage range of 2.5–5.0 mg THC in olive oil taken orally; twice daily N/A Psychopharmacological medications
Ruglass, 2017 Retrospective 98 Users: 41.63 (9.38), Non-Users: 44 (9.18) 136 136 52.21 Various varieties of cannabis; self-reported frequency Non-users' control Sertraline, riboflavin (for adherence)
Smith, 2017 Retrospective (chart audit) N/A 43 100 100 3 Various varieties of cannabis; dosage range of <5, 5-9, 10, & 10 < grams N/A Medications for pain, depression, anti-psychotic, bipolar disorder, anxiety, ADHD, seizures, muscle relaxants, nightmares, sleep, and related effects, such as erectile dysfunction and nausea
Wilkinson, 2015 Prospective 112 51.7 (8.6) 2276 2036 3.3 Various varieties of cannabis Cannabis use “stoppers”, “continuing users”, “starters”, & “non-users” N/A