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. 2021 Jun 10;12:689472. doi: 10.3389/fimmu.2021.689472

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Copyright © 2021 Smith and Burger

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Linear representation of BTK, PLCγ2 and CARD11 molecules showing amino acid replacements causing resistance to BTKi. The C481S replacement is the most common alteration and is marked with a red box. In PLCγ2, alterations induced by mutagenesis in mice are indicated as . Not all reported alterations are listed, only recurrent mutations have been included.

Inline graphic — Linear representation of BTK, PLCγ2 and CARD11 molecules showing amino acid replacements causing resistance to BTKi. The C481S replacement is the most common alteration and is marked with a red box. In PLCγ2, alterations induced by mutagenesis in mice are indicated as . Not all reported alterations are listed, only recurrent mutations have been included.