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. 2021 Jun 10;9:670186. doi: 10.3389/fbioe.2021.670186

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Copyright © 2021 Ellis, Dalwadi, Ellis, Byrne and Waters.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of (A) glucose conversion Q, Eqaution (3.3), (B) maximum lactate concentration W_max(T), Equation (3.2), where the red line represents the maximum tolerated lactate concentration, W = W_tol, and (C) proportion of domain which is uninhabitable at time T, P_U, Equation (3.4), for different organoid lines cultured within the bioreactor under the same operating conditions. The proliferation rates and rate of glucose consumption per cell for each organoid line are: (i) p = 1/6, ρ = 0.027, (ii) p = 1/6, ρ = 2.7, (iii) p = 1, ρ = 0.027, (iv) p = 1, ρ = 2.7, and (v) p = 1/3, ρ = 0.27. The other parameters used are given in Table 3. The line styles correspond to rate of cellular proliferation: solid, P = 1/6; dashed, P = 1/3; and dotted, P = 1. The line colours correspond to rate of glucose consumption per cell density: purple, ρ = 0.027; blue, ρ = 2.7; and green, ρ = 2.7.