Table 1.

Definitions of dimensional model parameters, together with typical values.

Parameter	Definition	Typical value
DCH	Diffusivity of glucose in hydrogel	6.0 × 10−10m2 s−1 (Suhaimi et al., 2015)
DCM	Diffusivity of glucose in media	6.0 × 10−10m2 s−1 (Suhaimi and Das, 2016)
DWH	Diffusivity of lactate in hydrogel	1.2 × 10−9m2 s−1 (Zhou et al., 2008)
DWM	Diffusivity of lactate in media	1.4 × 10−9m2 s−1 (Shipley et al., 2011)
c−∞	Glucose concentration in upstream reservoir	0.36 mol m−2
[u]	Maximum velocity of media flow	1 × 10−6 m s−1
L	Length of bioreactor	9 × 10−2m
hH	Height of hydrogel layer	1 × 10−3m
hM	Combined height of hydrogel and media	3 × 10−3m
N0	Initial cell seeding density	2.7 × 1010cell m−2 to 4 × 1010cell m−2
p	Proliferation rate	3.9 × 10−6s−1
νC	Rate of glucose consumption per unit cell density	9.4 × 10−17m2 cell−1 s−1

Where no citation is given, parameters are taken from the CPX1 set-up.