Table 3.

List of cellular metabolites significantly associated with cytarabine AUC values by Pearson correlation and categorical analysis in AML cell lines.

Metabolite	Ionization Set	Classification	Associated Pathway	Pearson r	p-value
Guanosine	Negative	Nucleosides	Purine metabolism	0.885	0.008
Aldopentose	Negative	Carbohydrates	Pentose Phosphate Pathway	0.866	0.012
4-Hydroxy-L- Phenylglycine	Positive	Xenobiotics	N/A	0.851	0.015
Guanine	Negative	Nucleosides	Purine metabolism	0.831	0.021
Guanine	Positive	Nucleosides	Purine metabolism	0.830	0.021
D-Raffinose	Negative	Sugars	Galactose metabolism	0.808	0.028
Glucosamine /Mannosamine	Positive	Sugars	Amino sugar and nucleotide sugar metabolism	0.804	0.029
Inosine	Negative	Nucleosides	Purine metabolism	0.797	0.032
Allopurinol	Positive	Xenobiotics	N/A	0.795	0.033
Metabolite	Ionization Set	Classification	Associated Pathway	Fold Change	p-value (t-test)
D-Raffinose	Negative	Sugars	Galactose metabolism	3.49	0.03
Guanosine	Negative	Nucleosides	Purine metabolism	2.72	0.04