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. 2021 Jun 10;9:590655. doi: 10.3389/fcell.2021.590655

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Copyright © 2021 Wohl and Sherman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparing the discrimination power of power spectral density (PSD)/amplitude spectral density (ASD) vs. mean square displacement (MSD) analyses for intracellular mechanical work. T-statistics values for the difference between cells before ATP depletion and the same cells after ATP depletion according to the two groups of parameters: ASD/PSD analysis based parameters in compare to MSD analysis based parameters. Corresponding parameters from the two groups are compared: the b parameter vs. α, sum of squared errors (SSE) of amplitudes vs. SSE of MSD’s, and “Sum of powers” vs. Sum of MSD’s. The t-statistics value for the ergodic test (described in “Results” section) is also presented. The P-values for the difference in t-statistics values between ASD/PSD parameters and the corresponding MSD parameters was calculated according to t-test for paired two samples and was found to be 0.03.