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. 2021 Jun 10;12:642842. doi: 10.3389/fimmu.2021.642842

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Copyright © 2021 Avila-Ponce de León, Vázquez-Jiménez, Matadamas-Guzman, Pelayo and Resendis-Antonio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TGEM in a breast cancer microenvironment. (A) We engineered different microenvironments associated with breast cancer and evaluate how our TGEM behaved. (B) Cell fate map of the theoretical genetically modified macrophage in breast cancer microenvironment for the expression of IgG and adenosines. (C) Cell fate map of the theoretical genetically modified macrophage in breast cancer microenvironment for the expression of IL1-β and IL-6. (D) Cell fate map of the theoretical genetically modified macrophage in breast cancer microenvironment for the expression of Hypoxia and glucocorticoids (GCGCR). (E) Cell fate map of the theoretical genetically modified macrophage in breast cancer microenvironment for the expression of IL-10 and TGF-β. This analysis was to evaluate the stability of our pharmaceutical approach in a breast cancer scenario.