TABLE 1.
Phospholipase A2 (PLA2) family and role of specific forms discussed in this review.
| Type | Group | Sub types | Other name | Molecular weight (kDa) | Catalytic residue | References | PLA2 forms discussed |
| cPLA2 | IV | α (A) β (B) γ (C) δ (D) ε (E) ζ (F) | 60–114 | Ser/asp | Dennis et al., 2011; Leslie, 2015 | cPLA2-IVα in lipid signaling | |
| iPLA2 | VI | β (A) γ (B) δ (C) ε (D) ζ (E) η (F) | PNPLA9 PNPLA8 PNPLA6 PNPLA3 PNPLA2 PNPLA4 | 27–146 | Ser/Asp | Dennis et al., 2011; Ramanadham et al., 2015 | iPLA2-VIβ in supporting focal exocytosis at the phagocytic cup |
| sPLA2 | I II III V IX X XI XII XIII XIV | A, B A, B, C, D, E, F A, B A, B | 10–19 | His/Asp | Dennis et al., 2011; Murakami et al., 2015; Murakami, 2017 | sPLA2-IIA, V, X, XII as antimicrobial forms at the phagocytic cup and within closed phagosomes | |
| LPLA2 | XV | 45 | Ser/His/Asp | Dennis et al., 2011; Fisher, 2018 | LPLA2 having bacteriocidal activity at the phagocytic cup and within phagolysosomes Also, its membrane repair mechanism | ||
| aiPLA2 | XVI | Peroxiredoxin 6 | 25 | Ser/His/Asp | Fisher, 2018 | aiPLA2regulating NOX2 assembly, and its membrane repair mechanism | |
| PAF-AH | VIIA VIIB VIII | Lp-PLA2, PLA2VII PAF-AH II PAF-AH I (PAFAH1B1 PAFAH1B2 PAFAH1B3) | 26–45 | Ser/His/Asp | Dennis et al., 2011; Karasawa and Inoue, 2015 | Not discussed as relevant information was not found |