FIGURE 3.
Changes in IgM and IgG concentration (A,B), N-ELISpot (C), and S-ELISpot (D) before and after vaccination with mRNA-1273 SARS-CoV-2 vaccine. Changes in the IgG titer in patients who were IgG(+) at baseline (E). Differences are analyzed by means of the Mann-Whitney test between groups and of the Wilcoxon signed-rank test for related samples within the same group along different time-points and an asterisk (*) identifies statistical significance. Bars identify medians. The Y-axis in Figure 3A–D is 10-logarithmic based, so patients with “0” SFU/2x105 PBMCs are not displayed