TABLE 3.

Univariable and multivariable analysis on factors associated with vaccine no-response according to antibodies or ELISpot results 2 weeks after the second dose of mRNA-1273 SARS-CoV-2 vaccine

	Vaccine no-response (Abs)				Vaccine no-response (ELISpot)
	Univariable	p-value	Multivariable	p-value	Univariable	p-value	Multivariable	p-value
Age
<50 years		.036	Ref	.192	Ref	.069	Ref	.229
51–60 years	4.27 [1.30–14.02]	.016	3.10 [0.80–11.94]	.100	2.59 [0.85–7.92]	.094	1.38 [0.38–4.99]	.616
61–70 years	3.83 [1.22–12.04]	.021	3.44 [0.92–12.83]	.065	1.12 [0.36–3.47]	.838	0.36 [0.08–1.54]	.170
>70 years	3.64 [1.20–11.04]	.022	3.21 [0.87–11.80]	.078	3.28 [1.10–9.79]	.033	0.94 [0.24–3.66]	.935
Sex (female)	1.85 [0.71–4.80]	.202			1.22 [0.54–2.75]	.618
Diabetes (yes)	1.77 [0.64–4.89]	.265			3.51 [1.42–8.67]	.006	5.65 [1.67–19.04]	.005
Type of transplant (kidney-pancreas vs. kidney)	0.69 [0.15–3.07]	.629			0.38 [0.07–2.00]	.257
Previous Tx (yes)	2.33 [0.80–6.76]	.117			0.90 [0.38–2.12]	.810
Baseline immunosuppression
TAC + MPA	Ref	.088	Ref	.067		.178
TAC + mTORi	0.35 [0.13–0.89]	.029	0.28 [0.09–0.82]	.020	1.95 [0.80–4.59]	.140
Belatacept	2.23 [0.25–19.65]	.469	1.73 [0.15–19.75]	.658	0.38 [0.07–2.02]	.260
Other	0.47 [0.15–1.48]	.201	0.34 [0.09–1.22]	.100	0.78 [0.26–2.30]	.662
ATG <1 year	7.00 [0.88–55.47]	.065	5.86 [0.63–53.96]	.119	6.10 [1.61–22.98]	.008	5.62 [0.89–35.53]	.065
Lymphopenia (yes)	1.39 [0.55–3.50]	.477			3.96 [1.65–9.45]	.002	2.80 [1.01–7.77]	.047
Time from Tx <1yr	1.85 [0.71–4.80]	.202			2.93 [1.27–6.78]	.012	1.23 [0.37–4.06]	.732
eGFR (ml/min/1.73m2)
>60	Ref	.070			Ref	.041	Ref	.077
45–60	0.50 [0.17–1.47]	.214	0.42 [0.12–1.43]	.166	3.12 [1.03–9.45]	.044	4.50 [1.25–16.18]	.021
30–45	0.90 [0.32–2.49]	.848	0.68 [0.21–2.23]	.535	3.12 [1.11–8.75]	.030	3.67 [1.13–11.97]	.030
<30	8.69 [1.02–73.99]	.048	5.45 [0.56–52.89]	.153	5.80 [1.72–19.57]	.005	4.11 [0.98–17.09]	.052

Bold values highlight statistical significance.