TABLE 4.
Univariable and multivariable analysis on factors associated with global vaccine no-response, defined as the negativity of both antibodies and ELISpot assay two weeks after the second dose of mRNA-1273 SARS-CoV-2 vaccine
| Vaccine no-response (neither Abs nor ELISpot) |
||||
|---|---|---|---|---|
| Univariable | p-value | Multivariable | p-value | |
| Age | ||||
| 50 years | Ref | .062 | .394 | |
| 51–60 years | 4.76 [1.30–17.46] | .018 | 2.50 [0.57–11.03] | .224 |
| 61–70 years | 2.35 [0.62–8.83] | .203 | 0.83 [0.16–4.29] | .826 |
| 70 years | 4.58 [1.29–16.26] | .018 | 1.26 [0.26–6.15] | .769 |
| Sex (female) | 1.55 [0.67–3.56] | .296 | ||
| Diabetes (yes) | 3.41 [1.41–8.22] | .006 | 4.65 [1.41–15.31] | .037 |
| Type of transplant (kidney-pancreas vs. kidney) |
0.59 [0.11–3.10] | .541 | ||
| Previous Tx (yes) | 1.27 [0.53–3.05] | .590 | ||
| Baseline immunosuppression | ||||
| TAC + MPA | Ref | .673 | ||
| TAC + mTORi | 1.26 [0.52–3.02] | .605 | ||
| Belatacept | 0.60 [0.11–3.25] | .554 | ||
| Other | 0.64 [0.20–2.04] | .455 | ||
| ATG <1yr | 10.07 [2.64–38.31] | .001 | 7.23 [1.12–46.51] | .037 |
| Lymphopenia (yes) | 3.82 [1.64–8.89] | .001 | 2.73 [0.96–7.71] | .058 |
| Time from Tx <1 year | 3.51 [1.52–8.08] | .003 | 1.14 [0.33–3.93] | .830 |
| eGFR (ml/min/1.73 m2) | ||||
| >60 | Ref | .024 | Ref | .161 |
| 45–60 | 1.11 [0.32–3.83] | .864 | 1.13 [0.26–4.91] | .866 |
| 30–45 | 2.83 [0.98–8.15] | .054 | 3.18 [0.92–10.95] | .066 |
| <30 | 4.95 [1.48–16.46] | .009 | 3.30 [0.78–14.01] | .105 |
Bold values highlight statistical significance.