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. 2021 Jun 9;90(1):174–175. doi: 10.1002/ana.26135

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© 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Neurofilament light chain (NfL) assay by Quanterix (Billerica, MA) HD‐X was used to measure NfL levels according to manufacturer's instructions. (A) Comparison of NfL levels in patients with COVID‐19 pneumonia at day 3 ± 1 and day 7 ± 1 (n = 18) and bacterial pneumonia at day 3 ± 1 (scatter dot blot with mean; n = 10) after onset of sepsis (analysis of variance on ranks, p < 0.001; Dunn multiple comparison test, ***p < 0.001). (B, C) Pearson correlation was used to assess correlations between neurofilaments and Sequential Organ Failure Assessment (SOFA) score (n = 36; day 3 ± 1 and 7 ± 1) or age (n = 18; day 3 ± 1) in COVID‐19 patients.