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. 2021 Jun 10;12:690821. doi: 10.3389/fimmu.2021.690821

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Copyright © 2021 Aradottir, Kristoffersson, Roumenina, Bjerre, Kashioulis, Palsson and Karpman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of factor D inhibition on hemolysis of rabbit erythrocytes. Factor B constructs were incubated in factor B-depleted serum with rabbit erythrocytes. The mutant variants D279G (positive control) and D371G (corresponding to Patient 1) induced hemolysis. The other mutant constructs (E601K, I242L) and wild-type (wt) did not induce hemolysis. The factor D inhibitor (FD-inh) inhibited hemolysis induced by factor B mutants D279G and D371G. Eight separate experiments are shown. ***P < 0.001, ****P < 0.0001.