TABLE 3.

The top overrepresented pathways identified through impact analysis of DEGs in the casesT1-controlsT1 comparison.

Pathway	Pathway ID	No. of genes (DE/All)	p-value	Overrepresented genes on pathway
Colorectal cancer	KEGG–05210	3/85	2.593 e-4	AREG, EREG, FOS
PI3K-AKT signaling	KEGG–04151 Reactome–R-HSA-2219530	8/314	2.617 e-4	AREG, THBS1, EREG, KITLG, ANGPT1, SGK2, TLR4, GNG2
Malaria	KEGG–05144	4/48	0.002	THBS1, CXCL8, SDC2, TLR4
Rheumatoid arthritis	KEGG–05323	5/85	0.003	CXCL8, ANGPT1, CCL3, TLR4, FOS
C-type lectin receptor signaling	KEGG–0425	4/103	0.003	EGR3, CLEC4D, CLEC4E, CLEC6A
Toll-like receptor signaling	KEGG–04620	5/93	0.006	CXCL8, CCL4, CCL3, TLR4, FOS
Cytokine signaling in the immune system	Reactome–R-HSA-1280215	9/676	0.0155	FOS, IRS2, IL1R2, MAPK8, LGALS9, BCL2, SERPINB2, CCL4