Table 1.
Summary of known viral proteins, targeted autophagic receptor and mechanism of inhibition/activation of autophagy
| Virus | Viral protein | Autophagic receptor | Inhibition (I)/ activation (A) of autophagy | Mechanism |
|---|---|---|---|---|
| HSV-1 | ICP0 | SQSTM1/p62 OPTN | I | Proteosomal targeting |
| HSV-1 | Unknown | CALCOCO2/NDP52 | I | Unknown |
| EBV | BPLF1 | SQSTM1/p62 | I | Deubiquitination |
| CSFV | Unknown | CALCOCO2/NDP52 | A | Deubiquitination/deSUMOylation |
| CVB3 | 2Cpro 3Cpro | SQSTM1/p62 NBR1 | I | Proteolytic cleavage |
| PV | Unknown | SQSTM1/p62 | I | Proteolytic cleavage |
| RV1A | Unknown | SQSTM1/p62 | I | Proteolytic cleavage |
| EV-D68 | Protease 3C | SQSTM1/p62 | I | Proteolytic cleavage |
| MeV | MeV-N | T6BP/TAX1BP1 | A | Unknown |
| MeV | MeV-C, MeV-V | CALCOCO2/NDP52 | A | Unknown |
| IAV | PB1-F2 | CALCOCO2/NDP52 | A | Unknown |
| HCV | NS3 | CALCOCO2/NDP52 | A | Unknown |
| CHIKV | nsP2 | CALCOCO2/NDP52 | A | Unknown |