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. 2021 Jun 15;24(2):585. doi: 10.3892/mmr.2021.12224

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Copyright: © Yin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Inhibition of NNT-AS1 suppresses the proliferation, migration and invasion of CRC cells. (A) The expression of NNT-AS1 was measured in normal colorectal cells (HCnEpC cells) and CRC cells (LoVo, RKO, SW48 and HCT116). (B) CRC cells (SW48 and HCT116) were transfected with the indicated siRNAs and the expression of NNT-AS1 was measured. (C) CRC cells were treated as indicated and cell viability was measured at different time points. (D) CRC cells were treated as indicated and the migration (left) and invasion (right) of cells were investigated. Data are presented as the mean ± standard deviation. *P<0.05, **P<0.01 and ***P<0.001 vs. HCnEpC or si-NC groups or as indicated. All experiments were conducted at least three times. NNT-AS1, lncRNA nicotinamide nucleotide transhydrogenase antisense RNA 1; CRC, colorectal cancer; si-, small interfering RNA; NC, negative control.