Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 10;9:645647. doi: 10.3389/fcell.2021.645647

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Wang, Min, Qiu, Wu, Liu, Ma, Zhang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Model for Xist and Xist regulation at the process of XCI. (A) The process of dynamic and multifaceted modulation of XCI by lncRNA Xist. lncRNA Xist is a multitasking RNA that recruits protein complexes (such as OCT4, CTCF, Tsix, Xite, PRC1, PRC2, SPEN, ATRX, hnRNPU, hnRNPK, SHARP, HDAC3, LBR, Airn, Kcnq1ot1, RBM15, WTAP, trisomy 21, U1 snRNP, Rsx, Sox2, PRDM14, Jpx, Rnf12, and RepA) to initiate, establish, and maintain the XCI state by histone modifications, DNA methylation, and H4 hypoacetylation. (B) LncRNA Xist regulation network of genetic interactions (Augui et al., 2011). Note that here arrows do not necessarily imply direct regulation.