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. 2021 Jun 10;11:592854. doi: 10.3389/fonc.2021.592854

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Copyright © 2021 Zheng, Hao, Xiang, Han, Shang, Zhen, Zhao, Zhang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPP1-related immune infiltration alteration. (A) Violin plot showing the ratio differentiation of 22 kinds of TICs in EGFR wild-type and mutant samples. Wilcoxon rank sum was used for the significance test. (B) Violin plot showing the ratio differentiation of 22 kinds of TICs in low and high SPP1 expression groups. (C) The correlation between different TICs subpopulations. (D) Differences in CD8+ T cells infiltration between EGFR mutation and wild-type patients with SPP1 high- or low-expression group. (E) Differences in M2 macrophages infiltration between EGFR mutation and wild-type patients with SPP1 high- or low-expression group.