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. 2021 Jun 9;12:669213. doi: 10.3389/fphar.2021.669213

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Copyright © 2021 Tian, Zeng, Zhao and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Angelicin alleviates PTOA development by regulating M1/M2 polarization. (A) Experiment design of treatment on LPS-induced mice. (B, C) Flow cytometry analysis of iNOS⁺F4/80⁺ and CD206⁺F4/80⁺macrophage in total bone marrow cells. (D, E) Immunostaining of iNOS and CD206 (red) in DMM model. Bar represents 200 μm. (F) Representative Safranin-O staining and H&E staining of cartilage and articular tissues from the different experimental groups (scale bar = 50 µm). (G) Diagram showing the OARSI scores of the articular cartilage.