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. 2021 Jun 9;12:669213. doi: 10.3389/fphar.2021.669213

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Copyright © 2021 Tian, Zeng, Zhao and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of the potential protective effects of angelicin in osteoarthritis development. Angelicin increased the phosphorylation of STAT3 and activated M2 macrophage polarization with the presence of LPS and IFN-γ.