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. 2021 Jun 15;24(2):582. doi: 10.3892/mmr.2021.12221

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — RBBP6 is a target gene of miR-193a-5p. (A) The dual-luciferase reporter assay was performed to verify that RBBP6 was a target gene of miR-193a-5p. (B) mRNA expression levels of RBBP6 in serum samples obtained from patients with EOC. (C) Protein and (D) mRNA expression levels of RBBP6 in epithelial ovarian cancer cell lines. Effect of miR-193a-5p overexpression on (E) protein and (F) mRNA expression levels of RBBP6. *P<0.05, **P<0.01 and ***P<0.001 vs. control or IOSE386; ^##P<0.01 and ^###P<0.001 vs. mimic-NC. RBBP6, RB binding protein 6, ubiquitin ligase; miR, microRNA; NC, negative control; WT, wild-type; MUT, mutant; luc, luciferase; R, Renilla.