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. 2021 Jun 23;157(8):1000–1002. doi: 10.1001/jamadermatol.2021.2114

Table. Self-reported Cutaneous Reactions After mRNA COVID-19 Vaccination.

Reaction No. (%) [95% CI]
Both mRNA vaccines Pfizer Moderna
Dose 1 reaction
No. 40 640 10 445 30 195
Cutaneous reactiona 776 (1.9) [1.78-2.05] 150 (1.4) [1.22-1.68] 626 (2.1) [1.92-2.24]
Itching or rashb 599 (1.5) [1.36-1.60] 128 (1.2) [1.02-1.46] 471 (1.6) [1.42-1.71]
Hives/urticaria 162 (0.4) [0.34-0.46] 25 (0.2) [0.15-0.35] 137 (0.5) [0.38-0.54]
Swelling/angioedema 120 (0.3) [0.24-0.35] 16 (0.2) [0.09-0.25] 104 (0.3) [0.28-0.42]
Recurrent dose 2 reaction
No. 609 124 485
Cutaneous reactiona 101 (17) [13.7-19.8] 20 (16) [10.14-23.81] 81 (17) [13.49-20.32]
Itching or rashb 81 (13) [10.7-16.3] 17 (14) [8.19-21.04] 64 (13) [10.31-16.54]
Hives/urticaria 20 (3.3) [2.02-5.03] 3 (2.4) [0.50-6.91] 17 (3.5) [2.05-5.55]
Swelling/angioedema 16 (2.6) [1.51-4.23] 3 (2.4) [0.50-6.91] 13 (2.7) [1.43-4.54]
New dose 2 reaction
No. 33 939 9055 24 884
Cutaneous reactiona 765 (2.3) [2.10-2.42] 128 (1.4) [1.18-1.68] 637 (2.6) [2.37-2.76]
Itching or rashb 546 (1.6) [1.48-1.75] 100 (1.1) [0.90-1.34] 446 (1.8) [1.63-1.96]
Hives/urticaria 194 (0.6) [0.49-0.66] 27 (0.3) [0.20-0.43] 167 (0.7) [0.57-0.78]
Swelling/angioedema 125 (0.4) [0.31-0.44] 15 (0.2) [0.09-0.27] 110 (0.4) [0.36-0.53]

Abbreviation: mRNA, messenger RNA.

a

Numbers do not sum to the total, as individual employees can report multiple cutaneous reactions.

b

Other than at injection site.