Table 1:
Clinical, histological, and molecular characteristics of UTROSCT.
| Case | Patient age (years) | Specimen type | Tumor size (cm) | Microscopic tumor margins | Tumor architecture | Cytomorphology | Mitoses (per 10 HPF) | NCOA1–3 fusion | NCOA1–3 fusion detection method | JAZF1/SUZ12/PHF1 rearrangement | Follow-Up (duration in months) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 51 | hysterectomy | 6 | Infiltrative | Sertoliform | Spindle and epithelioid | 4 | -- | -- | Negative | -- |
| 2 | 45 | EMC | at least 1.3 cm | Infiltrative | Corded, trabecular | Spindle and epithelioid | <1 | NCOA2 | FISH | Negative | -- |
| 3 | 48 | hysterectomy | 0.7 | Infiltrative | Corded, sertoliform | Spindle and epithelioid | <1 | ESR1-NCOA3 | FISH | Negative | NED (78.4) |
| 4 | 52 | hysterectomy | 0.5 | Infiltrative | Corded | Spindle and epithelioid | <1 | -- | -- | Negative | -- |
| 6 | 65 | hysterectomy | -- | Circumscribed | Nested, corded, trabecular | Epithelioid | 2 | -- | -- | Negative | -- |
| 7 | 71 | hysterectomy | 6.2 | Infiltrative | Nested, corded, whorled | Spindle and epithelioid | 1 | GREB1-NCOA1 | FISH and RNA-Seq |
Negative | NED (54.3) |
| 8 | 56 | hysterectomy | 0.9 | Infiltrative | Nested, corded, trabecular, sertoliform, retiform | Spindle and epithelioid | 1 | -- | -- | Negative | -- |
| 9 | 49 | hysterectomy | 2.7 | Infiltrative | Corded | Spindle and epithelioid (patchy signet ring cell morphology) | 16 | Negative | FISH | -- | -- |
| 10 | 31 | EMC | -- | Infiltrative | Nested, corded | Spindle and epithelioid | 3 | ESR1-NCOA3 | FISH | -- | -- |
| 11 | 49 | hysterectomy | 10 | Infiltrative | Corded, whorled, cystic | Spindle and epithelioid | 2 | Negative | FISH | -- | -- |
| 12 | 29 | myomectomy | -- | Infiltrative | Nested, sertoliform | Spindle and epithelioid (focally rhabdoid) | 2 | ESR1-NCOA3 | FISH | -- | -- |
| 13 | 20 | myomectomy | 7.7 | Infiltrative | Nested, corded | Epithelioid (rhabdoid) | 6 | ESR1-NCOA2 | FISH | -- | -- |
| 14 | 39 | hysterectomy | 3.2 | Infiltrative | Corded, trabecular, sertoliform | Spindle and epithelioid | 4 | ESR1-NCOA2 | FISH | -- | -- |
| 15 | 71 | EMC | -- | Infiltrative | Sertoliform, retiform | Spindle and epithelioid | <1 | GREB1-NCOA1 | FISH | -- | -- |
| 16 | 74 | hysterectomy | 13 | Infiltrative | Corded, trabecular, sertoliform, retiform | Spindle and epithelioid | 1 | GREB1-NCOA2 | FISH | -- | Recurrence to pelvis (66) |
| 17 | 57 | EMB | -- | Infiltrative | Nested | Epithelioid | <1 | ESR1-NCOA3 | FISH | -- | -- |
| 18 | 38 | EMC | 2 | Infiltrative | Retiform | Spindle and epithelioid | <1 | ESR1-NCOA3 | FISH | -- | NED (50) |
| 19 | 34 | hysterectomy | 3 | Infiltrative | Corded, trabecular | Spindle and epithelioid | <1 | ESR1-NCOA3 | FISH | -- | NED (319) |
| 20 | 55 | hysterectomy | 6 | Circumscribed | Corded, trabecular | Spindle and epithelioid | <1 | Negative | FISH and RNA-Seq |
Negative | NED (228) |
| 21 | 44 | hysterectomy | 2.5 | Infiltrative | Sertoliform, retiform | Spindle and epithelioid | <1 | ESR1-NCOA3 | FISH | -- | NED (23) |
| 22 | 45 | hysterectomy | 15 | Infiltrative | Sertoliform, retiform | Spindle and epithelioid | <1 | ESR1-NCOA3 | RNA-Seq | Negative | NED (207.2) |
| 23 | 54 | hysterectomy | 0.7 | Infiltrative | Corded, sertoliform, retiform | Spindle and epithelioid | <1 | ESR1-NCOA3 | RNA-Seq | Negative | NED (2) |
| 24 | 43 | hysterectomy | 0.4 | Infiltrative | Sertoliform, retiform | Spindle and epithelioid | <1 | Negative | RNA-Seq | Negative | NED (1) |
| 25 | 74 | EMB | at least 2.5 cm | Infiltrative | Sertoliform | Spindle and epithelioid | 3 | GREB1-NCOA1 | RNA-Seq | Negative | -- |
| 26 | 61 | hysterectomy | 8 | Infiltrative | Nested, corded, whorled | Spindle and epithelioid | 2 | GREB1-NCOA1 | RNA-Seq | Negative | NED (10) |
| 27 | 35 | myomectomy | -- | Infiltrative | Whorled | Spindle and epithelioid | <1 | ESR1-NCOA2 | RNA-Seq | Negative | -- |
| ///////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////// | |||||||||||
| *5 | 61 | hysterectomy | 11.5 | Circumscribed | Sertoliform, retiform | Spindle and epithelioid | <1 | Negative | FISH | JAZF1-SUZ12 | -- |
EMC (endometrial curetting); EMB (endometrial biopsy); HPF (high power fields, 400x); NED (no evidence of disease)
*
Excluded from statistics due to molecular translocation suggesting an endometrial stromal neoplasm
-- Not available/performed