Table 4:
Predictors of 1-Year Post-Transplant Mortality in Medically versus Mechanically Bridged Patients
|
Variable |
OR (95% CI) | p-value | OR (95% CI) | p-value |
|---|---|---|---|---|
| Univariable Analysis | ||||
| Medically Bridged | BTT w/ CF-LVAD | |||
| Age (years) | 1.02 (1.00 – 1.03) | 0.017 | 1.03 (1.01 – 1.04) | <0.001 |
| eGFR (mL/min/1.73m2) | 0.99 (0.99 – 1.00) | 0.008 | 0.98 (0.98 – 0.99) | <0.001 |
| PVR (Woods Units) | 1.06 (0.97 – 1.16) | 0.225 | 1.08 (1.01 –1.17) | 0.063 |
| BMI (kg/m2) | 1.00 (0.97 – 1.03) | 0.953 | 1.07 (1.04 – 1.09) | <0.001 |
| Ethnicity | 0.628 | 0.104 | ||
| White | (Reference) | (Reference) | ||
| African American | 0.85 (0.58 – 1.25) | 1.45 (1.06 – 1.97) | ||
| Hispanic | 0.93 (0.50 – 1.72) | 1.04 (0.61 – 1.79) | ||
| Other | 0.66 (0.26 – 1.66) | 1.44 (0.78 – 2.64) | ||
| Diabetes | 1.05 (0.76 – 1.45) | 0.785 | 1.42 (1.08 – 1.86) | 0.011 |
| History of Stroke | 1.12 (0.59 – 2.19) | 0.727 | 1.28 (0.81 – 2.01) | 0.297 |
| Smoking History | 0.89 (0.67 – 1.19) | 0.440 | 1.07 (0.83 – 1.40) | 0.596 |
| Implantable Defibrillator | 0.73 (0.50 – 1.06) | 0.099 | 1.01 (0.71 – 1.42) | 0.975 |
| Blood Type O | 1.14 (0.85 – 1.55) | 0.379 | 0.87 (0.66 – 1.14) | 0.317 |
| UNOS Status @ Listing | 0.264 | 0.030 | ||
| Status 1A | (Reference) | (Reference) | ||
| Status 1B | 0.74 (0.52 – 1.06) | 0.75 (0.55 – 1.01) | ||
| Status 2 | 0.86 (0.57 – 1.27) | 1.12 (0.80 – 1.57) | ||
| UNOS Status 1A @ Transplant | 0.99 (0.73 – 1.35) | 0.749 | 0.93 (0.71 – 1.22) | 0.612 |
| Functional Status @ Transplant | 0.847 | 0.265 | ||
| Poor | (Reference) | (Reference) | ||
| Moderate | 1.09 (0.77 – 1.53) | 0.93 (0.69 – 1.25) | ||
| Excellent | 1.09 (0.70 – 1.72) | 0.71 (0.46 – 1.09) | ||
| Wait Time > 6 Months | 1.09 (0.80 – 1.48) | 0.581 | 1.47 (1.12 – 1.92) | 0.005 |
| Ischemic Time (hours) | 1.09 (0.94 – 1.26) | 0.249 | 1.14 (1.01 – 1.28) | 0.041 |
| Donor Age (years) | 1.02 (1.01 – 1.03) | 0.001 | 1.00 (0.99 – 1.01) | 0.723 |
| Time on LVAD > 6 Months | --- | --- | 1.38 (1.05 – 1.82) | 0.020 |
| Multivariable Analysis | ||||
| Medically Bridged | BTT w/ CF-LVAD | |||
| Age (years) | 1.01 (0.99 – 1.02) | 0.212 | 1.02 (1.00 – 1.03) | 0.010 |
| eGFR (mL/min/1.73m2) | 0.99 (0.99 – 1.00) | 0.041 | 0.99 (0.98 – 0.99) | <0.001 |
| PVR (Woods Units) | 1.09 (1.00 – 1.17) | 0.044 | ||
| BMI (kg/m2) | 1.06 (1.03 – 1.09) | <0.001 | ||
| Diabetes | 1.06 (0.79 – 1.42) | 0.717 | ||
| Wait Time > 6 Months | 1.36 (1.03 – 1.80) | 0.031 | ||
| Ischemic Time (hours) | 1.13 (1.00 – 1.28) | 0.054 | ||
| Donor Age (years) | 1.02 (1.01 – 1.03) | 0.002 | ||
CVA, cerebrovascular accident; AICD, automated internal cardioverter defibrillator; BMI, body mass index; eGFR, estimated glomerular filtration rate; WL, waiting list; PA, pulmonary artery; PVR, pulmonary vascular resistance; UNOS, United Network for Organ Sharing; LVAD, left ventricular assist device.