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. 2021 Jun 8;6(24):15698–15707. doi: 10.1021/acsomega.1c00950

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© 2021 The Authors. Published by American Chemical Society

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MFS Transporter LacY family structure ensemble. The LacY structure is composed of a 6TMH domain duplication (colored slate and salmon) with a central cleft that binds the substrate (black spheres). LacY adopts (A) an inward facing and (B) an outward facing conformation. (C) Conformations are separated in a tree depicting distances between all LacY structures. (D) Inward-facing structure superpositions highlight flexibility (colored cyan and green) on the cytoplasmic side. (E) Outward facing structure superpositions highlight flexibility in the periplasmic gate (cyan), leading to partial occlusion of the substrate (green).