TABLE 2.
Clinical Prediction Tool to Detect Nonalcoholic Fatty Liver Disease in Crohn’s Disease (CPN-CD)
| Predictor Variable | Beta Coefficient | Odds Ratio (95% CI) | P | |
|---|---|---|---|---|
| CD duration ≥15 y | 0.668 | 2.0 (1.1–3.6) | 0.032 | |
| Black/African American | –1.996 | 0.1 (0.01–0.6) | 0.007 | |
| Postmenopausal female | 1.232 | 3.4 (1.5–8.1) | 0.005 | |
| Any cardiometabolic complications | 0.956 | 2.6 (1.3–5.1) | 0.006 | |
| Azathioprine or 6-MP | 0.871 | 2.4 (1.3–4.5) | 0.006 | |
| ALT, IU/L | <20 | Ref | Ref | Ref |
| 20–39.9 | 1.794 | 6.0 (2.9–12) | <0.001 | |
| ≥40 | 2.213 | 9.1 (3.8–22) | <0.001 | |
| BMI, kg/m2 | <27.5 | Ref | Ref | Ref |
| 27.5–34.9 | 1.062 | 2.9 (1.6–5.4) | 0.001 | |
| 35–37.4 | 1.884 | 6.6 (1.4–30) | 0.015 | |
| ≥37.5 | 2.768 | 16 (3.5–73) | <0.001 | |
| Constant | –3.336 |
Postmenopausal female was defined by the interaction of age and sex variables with females ≥50 years (coded as “1”) compared with either males (coded as “0”) or females aged <50 years (coded as “0”). Any cardiometabolic complication was coded as “0” or “1” for patients who were already known to have a clinical diagnosis of hypertension, dyslipidemia, impaired fasting glucose, diabetes mellitus, or coronary artery disease by manual review of the patient’s problem list (without using any specific a priori screening program or laboratory values).
Abbreviations: 6-MP, 6 mercaptopurine; CI, confidence interval.