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. 2021 Jun 24;21:319. doi: 10.1186/s12935-021-02026-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Effect of cervical cancer exosomes on endothelial cell vascularization. A Representative phase-contrast photomicrographs (magnification—100×) of endothelial tubular networks in Matrigel after 6 h in HUVEC co-incubated with exosomes (50 μg/ml) of different cervical cancer cell lines (upper row). Lower panels show corresponding quantitative evaluation of images by ImageJ Angiogenesis Analyzer plugin for meshes, nodes and tubes. B Effect of cervical cancer exosomes on total angiogenic profile. Cumulative data on number of nodes, branches, branch length and meshes of a representative experiment out of three independent experiments. Values are represented as mean ± s.d. (indicated as error bar). *p value ≤ 0.05 with respect to untreated HUVEC control