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. 2021 Jun 24;21:319. doi: 10.1186/s12935-021-02026-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Assessment of exosomal uptake in endothelial cells. Fluorescence photomicrographs showing HUVEC after 6 h incubation with SiHa, HeLa, and C33a-derived exosomes (50 μg/0.5 ml) labelled with PKH-67 dye (green). HUVEC were fixed in cold methanol and nuclei were counterstained with DAPI (blue; magnification—630×)