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. 2021 Jun 24;27:65. doi: 10.1186/s10020-021-00333-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Correlation between levels of IL-17A/GM-CSF and IL-17A/TNF in plasma and spleen of TLR4^−/− mice. Animals were injected with LPS (3 mg/kg, i.p.). At different time points upon sacrifice, the inflammatory mediators in blood and spleen were measured by Luminex™ as described in Materials and Methods. The plots show the Spearman’s correlations between levels of IL-17A/GM-CSF (A) and IL-17A/TNF (B) during the 0–12 h and 12–48 h time-intervals (the shaded area represents the 95% bootstrapped confidence interval)