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. 2021 Jun 24;40:209. doi: 10.1186/s13046-021-01972-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — TRAIL facilitates epithelial-mesenchymal transition (EMT) by regulating the expression of EMT-related proteins. a, b RT-qPCR of EMT-related genes in TRAIL-knockdown KYSE70 and KYSE150 cells. c Western blotting of EMT-related proteins in TRAIL-knockdown KYSE70 or KYSE150 cells and the respective controls. d–f mRNA and protein levels of EMT-related genes in TRAIL-overexpressing EC1 and TE1 cells. g Immunohistochemistry of vimentin and E-cadherin expression in TRAIL-overexpressing EC1 cells and respective controls. NC, negative control. The data are presented as the mean ± SEM. ***P < 0.001, **P < 0.01, *P < 0.05 (unpaired t-test)