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. 2021 Jun 10;8:682367. doi: 10.3389/fmolb.2021.682367

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Copyright © 2021 Zhao and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The suppressive effect of LPC on the proangiogenesis of EPCs. (A) A tube formation assay was used to examine the angiogenesis potential of EPCs in vitro. (B) Tubes developed by HUVECs in vitro. (C) Tubes developed by HUVECs cultured with the supernatant of EPCs in vitro. (D) After the PC treatment or (E) LPC treatment, the tubes formed by HUVECs that were cultured with supernatant of EPCs. (F,G) Tube count and capillary length of tubes in each group. ***p < 0.001 compared with the HUVECs group, ^# p < 0.05, ^## p < 0.01 compared with the EPCs + HUVECs group.