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. 2021 Feb 26;107(13):1032–1038. doi: 10.1136/heartjnl-2020-318060

Table 1.

Potential mechanisms of cardiovascular benefits associated with SGLT2-inhibitor therapy

Conventional mechanisms Novel mechanisms
Diuresis and reduction in blood pressure Improved myocardial energetics
Improved glycaemic control Improved myocardial ionic homeostasis
Weight loss Autophagy
Increase in red blood cell mass and haematocrit Altered adipokine regulation