Table 2.

OR and AP with 95% CI of developing MS among subjects with different numbers of DRB1*15:01 alleles exposed to the assessed lifestyle/environmental factor, compared with non-exposed DRB1*15:01 negative subjects

DRB1*15:01	Smoking	ca/co*	OR (95% CI)†	AP (95% CI)
0	+	1767/2258	1.5 (1.4 to 1.7)
1	+	1881/815	5.6 (4.9 to 6.3)	0.3 (0.2 to 0.4)
2	+	368/77	11.6 (8.8 to 15.3)	0.3 (0.02 to 0.6)
DRB1*15:01	Anti-EBNA-1 IgG	ca/co*	OR (95% CI)‡	AP (95% CI)
0	High	1474/1747	2.6 (2.3 to 2.9)
1	High	2033/758	10.0 (8.6 to 11.5)	0.5 (0.4 to 0.6)
2	High	445/87	19.5 (14.8 to 25.6)	0.5 (0.4 to 0.7)
DRB1*15:01	Adolescent BMI	ca/co*	OR (95% CI)§	AP (95% CI)
0	>25	392/467	1.4 (1.2 to 1.6)
1	>25	450/164	5.4 (4.4 to 6.7)	0.3 (0.1 to 0.4)
2	>25	87/15	12.5 (6.9 to 21.6)	0.3 (−0.1 to 0.7)

Based on data from online supplemental tables 2–4.

*Number of exposed cases and controls.

†Adjusted for study, age, sex, residential area, ancestry, EBNA-1 status, adolescent BMI, rs9277565, rs2229092, DRB1*03:01, DRB1*13:03, DRB1*08:01, A*02:01, B*44:02, B*38:01, B*55:01, DQA1*01:01, DQB1*03:02 and DQB1*03:01. Homozygote correction was made for DRB1*03:01 and A*02:01.

‡Adjusted for study, age, sex, residential area, ancestry, smoking, adolescent BMI, rs9277565, rs2229092, DRB1*03:01, DRB1*13:03, DRB1*08:01, A*02:01, B*44:02, B*38:01, B*55:01, DQA1*01:01, DQB1*03:02 and DQB1*03:01. Homozygote correction was made for DRB1*03:01 and A*02:01.

§Adjusted for study, age, sex, residential area, ancestry, smoking, EBNA-1 status, rs9277565, rs2229092, DRB1*03:01, DRB1*13:03, DRB1*08:01, A*02:01, B*44:02, B*38:01, B*55:01, DQA1*01:01, DQB1*03:02 and DQB1*03:01. Homozygote correction was made for DRB1*03:01 and A*02:01. AP, attributable proportion due to interaction.

AP, attributable proportion; BMI, body mass index; MS, multiple sclerosis.