Table 3.

OR with 95% CI of developing MS among subjects categorised by DRB1*15:01 and A*02:01 status

DRB1*15:01	A02:01	ca/co*	OR (95% CI)†	OR (95% CI)‡	AP (95% CI)
0	1–2	1232/2619	1.0 (reference)	1.0 (reference)
0	0	1861/2211	1.8 (1.6 to 2.0)	1.7 (1.5 to 1.8)
1	1–2	1520/974	3.3 (3.0 to 3.7)	3.7 (3.3 to 4.2)
1	0	1886/745	5.4 (4.8 to 6.0)	5.9 (5.4 to 7.1)	0.26 (0.17 to 0.35)
2	1–2	348/105	7.0 (5.5 to 8.8)	8.3 (6.8 to 11.5)
2	0	384/78	10.5 (8.1 to 13.6)	11.5 (9.2 to 16.4)	0.24 (0.003 to 0.5)

Attributable proportion due to interaction (AP).

DRB1*03:01, DRB1*13:03, DRB1*08:01, B*44:02, B*38:01, B*55:01, DQA1*01:01, DQB1*03:02 and DQB1*03:01. Homozygote correction was made for DRB1*03:01 and A*02:01.

*Number of exposed cases and controls.

†Adjusted for study, age, sex, residential area and ancestry.

‡Adjusted for study, age, sex, residential area, ancestry, smoking, EBNA-1 status, adolescent BMI, rs9277565, rs2229092.

MS, multiple sclerosis.