Table 4.

OR and AP with 95% CI of developing MS among A*02:01 negative subjects with different DRB1*15:01 status exposed to the assessed lifestyle/environmental factor, compared with non-exposed A*02:01 positive and DRB1*15:01 negative subjects

DRB1*15:01	A*02:01	Smoking	ca/co*	OR (95% CI)†
0	0	+	1045/1041	2.6 (2.2 to 3.0)
1	0	+	1016/342	9.3 (7.7 to 11.1)
2	0	+	193/29	20.0 (13.1 to 30.5)
DRB1*15:01	A*02:01	Anti-EBNA-1 IgG	ca/co*	OR (95% CI)‡
0	0	High	908/767	4.3 (3.5 to 4.9)
1	0	High	1152/334	14.9 (12.4 to 18.3)
2	0	High	237/35	28.7 (19.3 to 42.7)
DRB1*15:01	A*02:01	Adolescent BMI	ca/co*	OR (95% CI)§
0	0	>25	231/199	2.5 (2.0 to 3.1)
1	0	>25	229/75	8.0 (6.0 to 10.7)
2	0	>25	48/3	44.3 (13.5 to 145)

Based on data from online supplemental tables 5–7.

*Number of exposed cases and controls.

†Adjusted for study, age, sex, residential area, ancestry, EBNA-1 status, adolescent BMI, rs9277565, rs2229092, DRB1*03:01, DRB1*13:03, DRB1*08:01, B*44:02, B*38:01, B*55:01, DQA1*01:01, DQB1*03:02 and DQB1*03:01. Homozygote correction was made for DRB1*03:01.

‡Adjusted for study, age, sex, residential area, ancestry, smoking, adolescent BMI, rs9277565, rs2229092, DRB1*03:01, DRB1*13:03, DRB1*08:01, B*44:02, B*38:01, B*55:01, DQA1*01:01, DQB1*03:02 and DQB1*03:01. Homozygote correction was made for DRB1*03:01.

§Adjusted for study, age, sex, residential area, ancestry, smoking, EBNA-1 status, rs9277565, rs2229092, DRB1*03:01, DRB1*13:03, DRB1*08:01, B*44:02, B*38:01, B*55:01, DQA1*01:01, DQB1*03:02 and DQB1*03:01. Homozygote correction was made for DRB1*03:01.

AP, attributable proportion; MS, multiple sclerosis.