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. 2021 Mar 12;92(7):694–701. doi: 10.1136/jnnp-2020-325838

Table 1.

Comparison of the demographic and risk factor profile for cases with and without NOTCH3 variants

NOTCH3 variant carriers Non-NOTCH3 variant carriers P value
Number of cases 443 200 189
Mean (SD) age at recruitment (years) 55.7 (8.2), range 40–70 56.5 (8.2) range 38–72 0.06
Male sex (%) 223 (50) 89 872 (45) 0.02
White ethnic background (%) 378 (85) 187 912 (94) 1.53×10–15
Mean (SD) BMI (kg/m2) 27.8 (5.0) 27.4 (4.8) 0.12
Non-smoker (%) 399 (90.0) 180 955 (90.4) 0.82
Blood pressure medication (%) 37 (8.4) 20 171 (10.1) 0.23
Hypertension (%) 142 (32.1) 65 361 (32.6) 0.79
Hypercholesterolaemia (%) 49 (11.1) 19 085 (9.5) 0.27
Diabetes mellitus (%) 41 (9.3) 14 257 (7.1) 0.08

The p values for categorical and continuous variables were calculated by the Pearson’s Χ2 test and two-sample t-test, respectively.

BMI, body mass index.