Table 4.

Birth outcomes (n=1000)

	Controls (n=564)	Anti-TNF-α monotherapy (n=163)	P value	Thiopurine monotherapy (n=240)	P value	Anti-TNF-α and thiopurine (n=60)	P value
Birth weight in kg (IQR)	3.3 (3.0–3.7)	3.3 (2.9–3.7)	0.97	3.3 (3.0–3.6)	0.68	3.2 (2.7–3.5)	0.39
Gestational age in weeks (IQR)	39 (38–40)	39 (38–40)	0.55	39 (38–40)	0.07	39 (37–40)	0.09
Small for gestational age (%)	22 (4)	4 (3)	0.80	6 (3)	0.40	2 (3)	1.00
Preterm birth (%)	61 (11)	14 (10)	1.00	33 (14)	0.28	10 (17)	0.20
Major congenital abnormalities (%)	10 (2)	6 (4)	0.10	8 (3)	0.20	3 (5)	0.12
Caesarean section (%)	142 (25)	56 (42)	<0.01	75 (32)	0.06	18 (31)	0.35

Study groups were compared with controls. The Bonferroni correction was applied to adjust for multiple testing. A statistically significant difference was defined as a P < 0.02.

IQR, interquartile range; TNF, tumour necrosis factor.