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. 2021 Jun 10;12:678483. doi: 10.3389/fimmu.2021.678483

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Copyright © 2021 Del Campo, Bouley, Chevandier, Rousset, Haller, Indalecio, Guyon-Gellin, Le Vert, Hill, Djebali, Leverrier, Marvel, Combadière and Nicolas

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of influenza A nucleoprotein (NP) constructs. (A) Size distribution as measured by dynamic light scattering (left panel). The x-axis shows a distribution of size classes (nm) and the y-axis shows the relative volume distribution. Hydrodynamic diameters are obtained from scattering intensity DLS distributions. (B) Thermal stability as measured by nano differential scanning fluorimetry (right panel). The inflection temperature (Ti) values are mentioned. (C) Electron microscopy images. NP protein vaccines show different oligomeric states.