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. 2021 Jun 10;12:678483. doi: 10.3389/fimmu.2021.678483

Figure 3.

Figure 3

Long-term protection against viral challenges following OVX836 vaccination compared to NPm and NPwt. C57BL/6 mice (n = 12) were immunized twice 3 weeks apart (D0, D21), with 30 µg of NPm, NPwt, OVX836, or buffer (control mice) by the IM route. (A) 42 days and (B) 90 days post-first vaccination, mice were infected by IN route with 104.7 TCID50/20 μl (10 μl/nostril) of influenza H1N1 A/California/7/2009. Graph shows the percentage of survival observed among each group of mice. Buffer (dashed black), NPm (plain black), NPwt (green), and OVX836 (blue). *p < 0.05, **p < 0.01 and ***p < 0.001 by Log-Rank (Mantel–Cox) test.