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. 2021 Jun 10;12:666953. doi: 10.3389/fimmu.2021.666953

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Copyright © 2021 Diks, Khatri, Oosten, de Mooij, Groenland, Teodosio, Perez-Andres, Orfao, Berbers, Zwaginga, van Dongen and Berkowska

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between maximum expansion of memory B-cell subsets and vaccine-specific IgGs as determined by Spearman’s rank correlation. (A) Correlation between the maximum expansion of IgG1 memory B cells (ratio over baseline at days 7-28) and vaccine-specific IgGs (“Boostrix-IgG”) at days 14, 21 and 28. (B) Correlation between the maximum expansion of IgA1 memory B cells (ratio over baseline at days 7-28) and vaccine-specific IgGs at days 14, 21 and 28. An FDR-corrected p-value of <0.0075 was considered significant. D, Days after vaccination.