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. 2021 Jun 8;12:638066. doi: 10.3389/fimmu.2021.638066

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Copyright © 2021 Rychkov, Neely, Oskotsky, Yu, Perlmutter, Nititham, Carvidi, Krueger, Gross, Criswell, Ashouri and Sirota

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DE genes overlapped between synovium and whole blood tissues. Top Reactome common and different pathways for (A) Up-regulated and (B) downregulated genes. (C) Venn diagram of up- and down-regulated genes in synovium and blood: 29 common up-regulated genes (p =3e-09) and 4 common downregulated genes (p = 0.28). (D) Comparison scatter plot of fold changes between common genes in synovium and blood. Heatmap and PCA plots of common genes in (E, F) synovium and (G, H) blood. Vertical bars in the heatmap plots represent the color-coded coefficients of variation, Pearson correlations and log2 fold changes.