Table 2.
Univariate and multivariate analyses for predictors of disease-free survival
|
Factor
|
Univariable analysis
|
|
Multivariate analysis
|
|
|
|
|
AWGS2019
|
|
EWGSOP2
|
||||
|
|
HR (95%CI)
|
P
value
|
HR (95%CI)
|
P
value
|
HR (95%CI)
|
P
value
|
| AWGS2019 | 3.311 (2.470-4.439) | 0.001b | 2.150 (1.547-2.988) | 0.001b | ||
| EWGSOP2 | 2.566 (1.803-3.651) | 0.001b | 1.599 (1.092-2.339) | 0.016a | ||
| Age | 1.036 (1.021-1.051) | 0.001b | ||||
| Gender | ||||||
| Male/female | 1.038 (0.745-1.448) | 0.824 | ||||
| BMI | 0.934 (0.890-0.980) | 0.005b | ||||
| Albumin | 0.930 (0.904-0.957) | 0.001b | ||||
| Hypertension | ||||||
| Yes/No | 1.290 (0.948-1.755) | 0.105 | ||||
| Diabetes | ||||||
| Yes/No | 0.765 (0.476-1.229) | 0.268 | ||||
| ASA grade | ||||||
| II/I | 1.301 (0.773-2.190) | 0.323 | ||||
| III/I | 2.402 (1.366-4.225) | 0.002b | ||||
| CCI | 1.288 (1.146-1.448) | 0.001b | ||||
| Operative duration | 1.003 (1.001-1.006) | 0.017a | ||||
| TNM stage | ||||||
| II/I | 2.494 (1.349-4.610) | 0.004b | 1.660 (0.887-3.108) | 0.113 | 1.636 (0.872-3.067) | 0.125 |
| III/I | 8.093 (4.825-13.574) | 0.001b | 4.751 (2.753-8.200) | 0.001b | 4.968 (2.876-8.582) | 0.001b |
| Laparoscopic surgery | ||||||
| Yes/No | 0.463 (0.306-0.700) | 0.001b | ||||
| Type of resection | ||||||
| Total/Subtotal | 1.864 (1.400-2.481) | 0.001b | ||||
| Anastomosis method | ||||||
| B2/B1 | 2.571 (1.672-3.954) | 0.001b | 1.414 (0.904-2.210) | 0.129 | 1.423 (0.911-2.223) | 0.122 |
| RouY/B1 | 2.747 (1.920-3.390) | 0.001b | 1.614 (1.109-2.348) | 0.012a | 1.600 (1.100-2.328) | 0.014a |
| Lymph node dissection | ||||||
| D2/D1 | 1.036 (0.693-1.548) | 0.864 | ||||
| Histologic type | ||||||
| Undifferentiated/differentiated | 2.756 (1.855-4.095) | 0.001b | 1.899 (1.263-2.856) | 0.002b | 1.972 (1.309-2.970) | 0.001b |
| Total complications | 1.678 (1.221-2.307) | 0.001b | ||||
| Pneumonia | 2.574 (1.601-4.137) | 0.001b | 1.990 (1.222-3.241) | 0.006b | 1.935 (1.184-3.163) | 0.008b |
| Leakage | 3.325 (1.757-6.292) | 0.001b | 3.018 (1.557-5.853) | 0.001b | 3.339 (1.722-6.476) | 0.001b |
| Wound infection | 1.171 (0.435-3.153) | 0.755 | ||||
| Intestinal obstruction | 2.159 (0.888-5.252) | 0.090 | ||||
| Gastrointestinal dysfunction | 0.982 (0.484-1.994) | 0.960 | ||||
| Intra-abdominal infection | 1.410 (0.767-2.594) | 0.269 | ||||
| Intra-abdominal hemorrhage | 0.888 (0.365-2.160) | 0.794 | ||||
| Venous thrombosis | 0.997 (0.410-2.425) | 0.995 | ||||
| First time to Flatus | 1.101 (1.050-1.154) | 0.001b | ||||
| Hospital stay | 1.026 (1.017-1.035) | 0.001b | ||||
| Readmission within 30 d | 1.601 (0.929-2.759) | 0.090 |
a
P < 0.05.
b
P < 0.01. BMI: Body mass index; CCI: Charlson comorbidity index; ASA: American Society of Anesthesiologists; HR: Hazard ratio; CI: Confidence interval.